Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This rich volume is sure to attract scholarly attention in a variety of fields. There is nothing else like it in print.

Aristotle said that induction (epagōgē) is a proceeding from particulars to a universal, and the definition has been conventional ever since. But there is an ambiguity here. Induction in the Scholastic and the (so-called) Humean tradition has presumed that Aristotle meant going from particular statements to universal statements. But the alternate view, namely that Aristotle meant going from particular things to universal ideas, prevailed all through antiquity and then again from the time of Francis Bacon until the mid-nineteenth century. Recent (...) scholarship is so steeped in the first-mentioned tradition that we have virtually forgotten the other. In this essay McCaskey seeks to recover that alternate tradition, a tradition whose leading theoreticians were William Whewell, Francis Bacon, Socrates, and in fact Aristotle himself. The examination is both historical and philosophical. The first part of the essay fills out the history. The latter part examines the most mature of the philosophies in the Socratic tradition, specifically Bacon’s and Whewell’s. After tracing out this tradition, McCaskey shows how this alternate view of induction is indeed employed in science, as exemplified by several instances taken from actual scientific practice. In this manner, McCaskey proposes to us that the Humean problem of induction is merely an artifact of a bad conception of induction and that a return to the Socratic conception might be warranted. (shrink)

This is the first in-depth critical appraisal in English of the political, legal, and cultural writings of Carl Schmitt, perhaps this century's most brilliant critic of liberalism. It offers an assessment of this most sophisticated of fascist theorists without attempting either to apologise for or demonise him. Schmitt's Weimar writings confront the role of technology as it finds expression through the principles and practices of liberalism. Contemporary political conditions such as disaffection with liberalism and the rise of extremist political organizations (...) have rendered Schmitt's work both relevant and insightful. John McCormick examines why technology becomes a rallying cry for both right- and left-wing intellectuals at times when liberalism appears anachronistic, and shows the continuities between Weimar's ideological debates and those of our own age. (shrink)

This wide-ranging, multidisciplinary collection of newly commissioned articles brings together distinguished voices in the field of Africana philosophy and African-American social and political thought. Provides a comprehensive critical survey of African-American philosophical thought. Collects wide-ranging, multidisciplinary, newly commissioned articles in one authoritative volume. Serves as a benchmark work of reference for courses in philosophy, social and political thought, cultural studies, and African-American studies.

It will engage bioethicists and philosophers as well as inform policy and law regarding issues at the beginning and end of life.

Used as the basis of the program at the Equinox Holistic Alternative School in Toronto, The Holistic Curriculum advocates for an integrative approach to teaching and learning with a focus on developing a deep connection between mind and body.

Introduces the use of Lego Robots for use in research and teaching in philosophy. Potential uses include using the machines as pedagogical tools for teaching introductory ideas in cognitive robotics, philosophy of mind, and the philosophy of Artificial Intelligence. Describes the strength and potential pitfalls of introducing this technology to the classroom.

In this original work of psychoanalytic theory, John Muller explores the formative power of signs and their impact on the mind, the body and subjectivity, giving special attention to work of the French psychoanalyst Jacques Lacan and the American philosopher Charles Sanders Peirce. Muller explores how Lacan's way of understanding experience through three dimensions--the real, the imaginary and the symbolic--can be useful both for thinking about cultural phenomena and for understanding the complexities involved in treating psychotic patients. Muller develops (...) Lacan's perspective gradually, presenting it as distinctive approaches to data from a variety of sources, such as cognitive, social and developmental psychology, literature, history, art, and psychoanalytic treatment. The book's first four chapters present Muller's reading of selected data from child development research, psychology and linguistics, approximating a semiotic model of "normal" development. The following three chapters examine in a Lacanian framework the structural basis of psychotic stages as indicative of massive semiotic failure in development. The final chapters on human narcissism suggest reasons that "normal" development may be impossible. (shrink)

How induction was understood took a substantial turn during the Renaissance. At the beginning, induction was understood as it had been throughout the medieval period, as a kind of propositional inference that is stronger the more it approximates deduction. During the Renaissance, an older understanding, one prevalent in antiquity, was rediscovered and adopted. By this understanding, induction identifies defining characteristics using a process of comparing and contrasting. Important participants in the change were Jean Buridan, humanists such as Lorenzo Valla and (...) Rudolph Agricola, Paduan Aristotelians such as Agostino Nifo, Jacopo Zabarella, and members of the medical faculty, writers on philosophy of mind such as the Englishman John Case, writers of reasoning handbooks, and Francis Bacon. (shrink)

"The Treatise on the Origin of Humanity (Yuanren lun) by the Huayan patriarch Zongmi classifies various teachings of Buddhism on a scale of relative profundity, and specifically critiques the weaknesses of the teachings of Confucianism and Daoism, which he regards as inferior to Buddhism. This work formed the basis for some of the arguments in later East Asian history on the relationship of the three teachings." --.

The author argues that the core of Hume’s Academic skepticism lies in his commitment to an external world and objective causal powers that are cognitively opaque to human understanding. Three central topics of Hume’s theory of the understanding are discussed—the existence of absolute space, the existence of a world external to our senses, and the existence of objective causal powers. In each case, Hume draws a Pyrrhonian opposition between judgments based on his “Copy Principle” and the “fictions” or “illusions” formed (...) through association of ideas. While he suspends judgment concerning the existence of absolute space, he argues that the association-based beliefs in an external world and objective causal powers are necessary for human life and indispensible in science. In adopting such beliefs about external reality, while at the same time denying their intelligibility, Hume was following ancient Academic skepticism. (shrink)

By utilizing new information from both clinical and experimental (lesion, electrophysiological, and gene-activation) studies with animals, the anatomy underlying anterograde amnesia has been reformulated. The distinction between temporal lobe and diencephalic amnesia is of limited value in that a common feature of anterograde amnesia is damage to part of an comprising the hippocampus, the fornix, the mamillary bodies, and the anterior thalamic nuclei. This view, which can be traced back to Delay and Brion (1969), differs from other recent models in (...) placing critical importance on the efferents from the hippocampus via the fornix to the diencephalon. These are necessary for the encoding and, hence, the effective subsequent recall of episodic memory. An additional feature of this hippocampalanterior thalamic and the perirhinal–medial dorsal thalamic systems are compromised, leading to severe deficits in both recall and recognition. (shrink)

Numbers and other mathematical objects are exceptional in having no locations in space or time or relations of cause and effect. This makes it difficult to account for the possibility of the knowledge of such objects, leading many philosophers to embrace nominalism, the doctrine that there are no such objects, and to embark on ambitious projects for interpreting mathematics so as to preserve the subject while eliminating its objects. This book cuts through a host of technicalities that have obscured previous (...) discussions of these projects, and presents clear, concise accounts of a dozen strategies for nominalistic interpretation of mathematics, thus equipping the reader to evaluate each and to compare different ones. The authors also offer critical discussion, rare in the literature, of the aims and claims of nominalistic interpretation, suggesting that it is significant in a very different way from that usually assumed. (shrink)

Darwinism, Democracy, and Race examines the development and defence of an argument that arose at the boundary between anthropology and evolutionary biology in twentieth-century America. In its fully articulated form, this argument simultaneously discredited scientific racism and defended free human agency in Darwinian terms. The volume is timely because it gives readers a key to assessing contemporary debates about the biology of race. By working across disciplinary lines, the book's focal figures--the anthropologist Franz Boas, the cultural anthropologist Alfred Kroeber, the (...) geneticist Theodosius Dobzhansky, and the physical anthropologist Sherwood Washburn--found increasingly persuasive ways of cutting between genetic determinist and social constructionist views of race by grounding Boas's racially egalitarian, culturally relativistic, and democratically pluralistic ethic in a distinctive version of the genetic theory of natural selection. Collaborators in making and defending this argument included Ashley Montagu, Stephen Jay Gould, and Richard Lewontin. Darwinism, Democracy, and Race will appeal to advanced undergraduates, graduate students, and academics interested in subjects including Philosophy, Critical Race Theory, Sociology of Race, History of Biology and Anthropology, and Rhetoric of Science. (shrink)

While we are commonly told that the distinctive method of mathematics is rigorous proof, and that the special topic of mathematics is abstract structure, there has been no agreement among mathematicians, logicians, or philosophers as to just what either of these assertions means. John P. Burgess clarifies the nature of mathematical rigor and of mathematical structure, and above all of the relation between the two, taking into account some of the latest developments in mathematics, including the rise of experimental (...) mathematics on the one hand and computerized formal proofs on the other hand. Along the way, a great many historical developments in mathematics, philosophy, and logic are surveyed. Yet very little in the way of background knowledge on the part of the reader is presupposed. (shrink)

In this paper Sullins argues that in certain circumstances robots can be seen as real moral agents. A distinction is made between persons and moral agents such that, it is not necessary for a robot to have personhood in order to be a moral agent. I detail three requirements for a robot to be seen as a moral agent. The first is achieved when the robot is significantly autonomous from any programmers or operators of the machine. The second is when (...) one can analyze or explain the robot's behavior only by ascribing to it some predisposition or 'intention' to do good or harm. And finally, robot moral agency requires the robot to behave in a way that shows and understanding of responsibility to some other moral agent. Robots with all of these criteria will have moral rights as well as responsibilities regardless of their status as persons. (shrink)

The debate over whether brain death is death has focused on whether individuals who have sustained total brain failure have satisfied the biological definition of death as “the irreversible loss of the integration of the organism as a whole.” In this paper, I argue that what it means for an organism to be integrated “as a whole” is undefined and vague in the views of those who attempt to define death as the irreversible loss of the integration of the organism (...) as a whole. I show how what it means for a living thing to be integrated as a whole depends on the sortal concept by which it is identified. Since interests, values, and ontological considerations besides strictly biological ones affect the concepts by which we individuate and identify living things, those non-biological considerations have a bearing on what it means for a particular kind of living thing to exist as a whole and thus what it means for one of us to die. Even if our bodies may remain organically integrated in some sense despite total brain failure, this fact should not lead us to reject brain death as death. Artificially sustained brain-dead human bodies are not human beings, but the remains of them. While such bodies may be alive in some sense, they are not human beings or human persons. They are not one of us. (shrink)

Highlighting previously neglected democratic strains in Machiavelli's major writings, McCormick excavates institutions through which the common people of ancient, medieval, and Renaissance republics constrained the power of wealthy citizens and public magistrates, and he imagines how such institutions might be revived today.

This book surveys the assortment of methods put forth for fixing Frege's system, in an attempt to determine just how much of mathematics can be reconstructed in ...

Philosophical Logic is a clear and concise critical survey of nonclassical logics of philosophical interest written by one of the world's leading authorities on the subject. After giving an overview of classical logic, John Burgess introduces five central branches of nonclassical logic, focusing on the sometimes problematic relationship between formal apparatus and intuitive motivation. Requiring minimal background and arranged to make the more technical material optional, the book offers a choice between an overview and in-depth study, and it balances (...) the philosophical and technical aspects of the subject.The book emphasizes the relationship between models and the traditional goal of logic, the evaluation of arguments, and critically examines apparatus and assumptions that often are taken for granted. Philosophical Logic provides an unusually thorough treatment of conditional logic, unifying probabilistic and model-theoretic approaches. It underscores the variety of approaches that have been taken to relevantistic and related logics, and it stresses the problem of connecting formal systems to the motivating ideas behind intuitionistic mathematics. Each chapter ends with a brief guide to further reading.Philosophical Logic addresses students new to logic, philosophers working in other areas, and specialists in logic, providing both a sophisticated introduction and a new synthesis. (shrink)

Introduction A brief look at the competing present-day interpretations of Hume's philosophy will leave the uninitiated reader completely baffled. On the one hand , Hume is seen as a philosopher who attempted to analyse concepts with ...

The great logician Gottlob Frege attempted to provide a purely logical foundation for mathematics. His system collapsed when Bertrand Russell discovered a contradiction in it. Thereafter, mathematicians and logicians, beginning with Russell himself, turned in other directions to look for a framework for modern abstract mathematics. Over the past couple of decades, however, logicians and philosophers have discovered that much more is salvageable from the rubble of Frege's system than had previously been assumed. A variety of repaired systems have been (...) proposed, each a consistent theory permitting the development of a significant portion of mathematics. This book surveys the assortment of methods put forth for fixing Frege's system, in an attempt to determine just how much of mathematics can be reconstructed in each. John Burgess considers every proposed fix, each with its distinctive philosophical advantages and drawbacks. These systems range from those barely able to reconstruct the rudiments of arithmetic to those that go well beyond the generally accepted axioms of set theory into the speculative realm of large cardinals. For the most part, Burgess finds that attempts to fix Frege do less than advertised to revive his system. This book will be the benchmark against which future analyses of the revival of Frege will be measured. (shrink)

Critics of organ donation after circulatory death (DCD) argue that, even if donors are past the point of autoresuscitation, they have not satisfied the “irreversibility” requirement in the circulatory and respiratory criteria for determining death, since their circulation and respiration could be artificially restored. Thus, removing their vital organs violates the “dead-donor” rule. I defend DCD donation against this criticism. I argue that practical medical-ethical considerations, including respect for do-not-resuscitate orders, support interpreting “irreversibility” to mean permanent cessation of circulation and (...) respiration. Assuming a consciousness-related formulation of human death, I then argue that the loss of circulation and respiration is significant, because it leads to the permanent loss of consciousness and thus to the death of the human person. The DNR request by an organ donor should thus be interpreted to mean “do not restore to consciousness.” Finally, I respond to an objection that if “irreversibility” has a medical-ethical meaning, it would entail the absurd possibility that one of two individuals in the same physical state could be alive and the other dead—an implication that some think is inconsistent with understanding death as an objective biological state of the organism. I argue that advances in medical technology have created phenomena that challenge the assumption that human death can be understood in strictly biological terms. I argue that ethical and ontological considerations about our nature bear on the definition and determination of death and thus on the permissibility of DCD. (shrink)

(2013). Informed Consent, Big Data, and the Oxymoron of Research That Is Not Research. The American Journal of Bioethics: Vol. 13, No. 4, pp. 40-42. doi: 10.1080/15265161.2013.768864.

The most important distinctively American contribution to philosophy is the pragmatist tradition. In this short, lucid, and completely convincing exposition, Professor John P. Murphy begins by exploring the roots of this tradition as found in the work of Peirce, James, and Dewey, demonstrating its power and originality. Historians of philosophy will appreciate the insight Murphy brings to these figures, but the special value of this book lies in his discussion of how the pragmatist spirit has flowered in contemporary philosophy (...) in the work of Quine, Rorty, and Davidson.Throughout, Murphy emphasizes the logic and structure of the views held by these six philosophers and what it is they have in common that makes their work especially “pragmatist.” There is no better introduction to this historical tradition and perhaps no better way into the philosophies of the contemporaries whom Murphy discusses.Interest in pragmatist ideas is undergoing a revival at present, and this book shows us why. It will be of interest to both historians of philosophy and students of contemporary philosophy. (shrink)

What role do moment‐to‐moment comprehension processes play in visual attentional selection in picture stories? The current work uniquely tested the role of bridging inference generation processes on eye movements while participants viewed picture stories. Specific components of the Scene Perception and Event Comprehension Theory (SPECT) were tested. Bridging inference generation was induced by manipulating the presence of highly inferable actions embedded in picture stories. When inferable actions are missing, participants have increased viewing times for the immediately following critical image (Magliano, (...) Larson, Higgs, & Loschky, ). This study used eye‐tracking to test competing hypotheses about the increased viewing time: (a) Computational Load: inference generation processes increase overall computational load, producing longer fixation durations; (b) Visual Search: inference generation processes guide eye‐movements to pick up inference‐relevant information, producing more fixations. Participants had similar fixation durations, but they made more fixations while generating inferences, with that process starting from the fifth fixation. A follow‐up hypothesis predicted that when generating inferences, participants fixate scene regions important for generating the inference. A separate group of participants rated the inferential‐relevance of regions in the critical images, and results showed that these inferentially relevant regions predicted differences in other viewers’ eye movements. Thus, viewers’ event models in working memory affect visual attentional selection while viewing visual narratives. (shrink)

One approach to the problem of differentiating a religious from a non- religious ethic would be to formulate a definition of religion that would clearly distinguish between religious and nonreligious traditions; however, a broad definition of religion would include some moral traditions, such as Marxism, commonly thought to be forms of secular humanism. A second approach would argue that some moral beliefs are independent, both in content and justification, of religious convictions; such a set of moral beliefs could be described (...) as a secular version of natural law. This approach would be rejected by those who argue that religious convictions go "all the way down." While the first can be debated by appealing to the heuristic value of various definitions of religion, the second involves familiar issues of moral epistemology. The author explores the consequences of holding a broad definition of religion and an "all the way down" epistemology. (shrink)

Scientific authorship has become a contested terrain in contemporary science. Based on a survey of authors across fields, we measure the likelihood of specialist authors : people who only made specialized contributions, such as data, materials, or funding; and “nonauthor collaborators” : those who did significant work on the project but do not appear as authors, across different research contexts, including field, size of the project team, commercial orientation, impact of publication, and organization of the collaboration. We find that guest (...) and ghost authors are common, with about one-third of publications having at least one specialist author and over half having at least one nonauthor collaborator. We see significant cross-field variations in both overall rates and types of specialist authors and nonauthor collaborators. We find there are generally fewer specialist authors among highly cited papers and more graduate student nonauthor collaborators in single location projects. The results suggest authorship practices vary across fields, and by project characteristics, complicating the use of authorship lists as a basis for evaluation. We discuss implications of these findings for interpreting author lists in the context of science policy. (shrink)

This book will appeal to mathematicians and philosophers interested in the foundations of mathematics.

This volume reprints a dozen of the author’s papers, most with substantial postscripts, and adds one new one. The bulk of the material is on topics in philosophy of language, but there are also two papers on philosophy of mathematics written after the appearance of the author’s collected papers on that subject, and one on epistemology. As to the substance of Field’s contributions, limitations of space preclude doing much more below than indicating the range of issues addressed, and the general (...) orientation taken towards them. As to the style of his writing, it well exhibits the first of the two virtues, clarity and conciseness, that one looks for in philosophical prose. (shrink)

The source, status, and significance of the derivation of the necessity of identity at the beginning of Kripke’s lecture “Identity and Necessity” is discussed from a logical, philosophical, and historical point of view.

The complexity of the set of truths of arithmetic is determined for various theories of truth deriving from Kripke and from Gupta and Herzberger.

Mathematics tells us there exist infinitely many prime numbers. Nominalist philosophy, introduced by Goodman and Quine, tells us there exist no numbers at all, and so no prime numbers. Nominalists are aware that the assertion of the existence of prime numbers is warranted by the standards of mathematical science; they simply reject scientific standards of warrant.

Medical necessity (claiming that a medical intervention or care is – at minimum – reasonable, appropriate and acceptable) depends on empirical evidence and on the interpretation of that evidence. Evidence and its interpretation define the standard of care. This commentary argues that both the evidence base and its interpretation are currently weak gatekeepers. Empirical meta-research suggests that very few medical interventions have high quality evidence in support of their effectiveness and very few of them also have relatively thorough assessments of (...) their potential harms. Therefore, evidence on the risk-benefit ratios carries almost always very large uncertainty. Arbitration about medical necessity is thus left to the interpretation process. Professional guidelines are notoriously unreliable and biased in this regard. Regulatory approval ends up being the key arbitrator, but over the years the regulatory process has been subverted. Regulatory approval currently does not mean that an intervention has a favourable risk-benefit ratio, but simply that it can be marketed, sold and made profit from. The process leads to a tragedy of commons where the final victim is society at large: medical necessity is invoked as an alibi for medicine to absorb societal resources. (shrink)

The form of nominalism known as 'mathematical fictionalism' is examined and found wanting, mainly on grounds that go back to an early antinominalist work of Rudolf Carnap that has unfortunately not been paid sufficient attention by more recent writers.

In order to sketch an account of a moral commitment to persons as such, the essay examines empathy, sympathy, and benevolence as they arise first in special relations and then are reconstructed to include the stranger under the rubric of "extensive benevolence" or "universal love." The account, the author argues, must deal with conceptual empowerment and authorizing reasons, weakness and evil, normative conflict, and the relation of benevolence to justice.

There has been growing concern about whether individuals who satisfy neurological criteria for death or who become non-heart-beating organ donors are really dead. This concern has focused on the issue of the potential for recovery that these individuals may still have and whether their conditions are irreversible. In this article I examine the concepts of potentiality and irreversibility that have been invoked in the discussions of the definition of death and non-heart-beating organ donation. I initially focus on the recent challenge (...) by D. Alan Shewmon to accepting any neurological criterion of death. I argue that Shewmon relies on a problematic and unrealistic concept of potentiality, and that a better, more realistic concept of potentiality is consistent with accepting a neurological criterion for death. I then turn to an analysis of how the concept of irreversibility has been used in discussion of non-heart-beating organ donation. Similarly, I argue that some participants in this discussion have invoked a problematic and unrealistic concept of irreversibility. I then propose an alternative, more realistic account of irreversibility that explains how "irreversibility" should be understood in the definition and criteria of death. (shrink)